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These medications are best suited for individuals who meet one or more of the following criteria: Body mass index (BMI) ≥30 kg/m², or ≥27 kg/m² with comorbid conditions Significant insulin resistance despite lifestyle modification and metformin Difficulty achieving weight loss through conventional means No immediate plans for pregnancy (due to limited safety data in pregnancy) Healthcare providers should also consider contraindications such as a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2
